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In postmarketing reportscases of drug-induced hepatotoxicity have been reported in the first monthand in some casesthe first 2 months of therapybut can occur at any time during treatment sildenafil india price. with diclofenacPostmarketing surveillance has reported cases of severe hepatic reactionsincluding liver necrosisjaundicefulminant hepatitis with and without jaundiceand liver failureSome of these reported cases resulted in fatalities or liver transplantation.
Advise patients to be alert for the symptoms of congestive heart failure including shortness of breathunexplained weight gainor edema and to contact their healthcare provider if such symptoms occursee WARNINGSHeart Failure And Edema
Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleedingThe concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug aloneSerotonin release by platelets plays an important role in hemostasisCase-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone.
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