Conversion of patients to oral immediate-release carbidopa-levodopatablets in preparation for sinemet sr treatment.
Information about Sinemet.
Other side effects not listed above may also occur in some patientsTell your doctor if you notice any other effects.
Patients taking SINEMET alone or with other dopaminergic drugs have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily livingincludes operation of motor vehiclesRoad traffic accidents attributed to sudden sleep onset have been reportedAlthough many patients reported somnolence while on dopaminergic medicationsthere have been reports of road traffic accidents attributed to sudden onset of sleep in which the patient did not perceive any warning signssuch as excessive drowsinessand believed that they were alert immediately prior to the eventSudden onset of sleep has been reported to occur as long as one year after the initiation of treatment.
Current evidence indicates that symptoms of Parkinson’s disease are related to depletion of dopamine in the corpus striatumAdministration of dopamine is ineffective in the treatment of Parkinson’s disease apparently because it does not cross the blood-brain barrierHoweverlevodopathe metabolic precursor of dopaminedoes cross the blood-brain barrierand presumably is converted to dopamine in the brainThis is thought to be the mechanism whereby levodopa relieves symptoms of Parkinson’s disease.
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tell your doctor if you or your family carer notices you are developing addiction-like symptoms leading to craving for large doses of sinemet and other medicines used to treat parkinson s disease.