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The medication may also be used to treat seizuresinfectionsand pain caused by pancreas diseaseIt is sometimes used to improve survival after bypass surgeryprevent rejection of kidney transplantsor reduce ulcer relapses.
The reports that the concomitant use of Zyloprim and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causationReview of these case reports indicates that the patients were mainly receiving thiazide diuretics for hypertension and that tests to rule out decreased renal function secondary to hypertensive nephropathy were not often performedIn those patients in whom renal insufficiency was documentedhoweverthe recommendation to lower the dose of Zyloprim was not followedAlthough a causal mechanism and a cause-and-effect relationship have not been establishedcurrent evidence suggests that renal function should be monitored in patients on thiazide diuretics and Zyloprim even in the absence of renal failureand dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.
Kidney functionKidney disease or reduced kidney function may cause this medication to build up in the bodycausing side effectsIf you have reduced kidney function or kidney diseasediscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is needed.
Some patients with pre-existing renal disease or poor urate clearance have shown a rise in BUN during administration of ZyloprimAlthough the mechanism responsible for this has not been establishedpatients with impaired renal function should be carefully observed during the early stages of administration of Zyloprim and the dosage decreased or the drug withdrawn if increased abnormalities in renal function appear and persist.
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