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The fda issued a clozaril black box warning for its potential for serious and potentially life-threatening adverse reactions, and thus is normally used for very severe and refractory schizophrenia that does not respond to other pharmacological treatment.

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With schizophrenia who are non-responsive to or intolerant of antipsychotic medicationor with psychosis in Parkinson’s disease when other treatment strategies have failedsee section 4.1

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It may take several weeks before the full benefit of this drug takes effectInform your doctor if your condition persists or worsens.

Patients who develop clozapine-induced myocarditis or cardiomyopathy should not be re-exposed to clozapinesee section 4.3 and 4.4

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in a pooled data analysis of 8 studies in adult subjects with schizophrenia, the mean changes in fasting glucose concentration in the clozaril and chlorpromazine groups were 11 mg dl and 4 mg dl respectively.

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