The fda issued a clozaril black box warning for its potential for serious and potentially life-threatening adverse reactions, and thus is normally used for very severe and refractory schizophrenia that does not respond to other pharmacological treatment.
Information about Clozaril.
With schizophrenia who are non-responsive to or intolerant of antipsychotic medicationor with psychosis in Parkinson’s disease when other treatment strategies have failedsee section 4.1
Liver problemsnauseaupper stomach painloss of appetitetirednessconfusionunusual bleedingdark urineclay-colored stoolsjaundiceyellowing of the skin or eyes
It may take several weeks before the full benefit of this drug takes effectInform your doctor if your condition persists or worsens.
Patients who develop clozapine-induced myocarditis or cardiomyopathy should not be re-exposed to clozapinesee section 4.3 and 4.4
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in a pooled data analysis of 8 studies in adult subjects with schizophrenia, the mean changes in fasting glucose concentration in the clozaril and chlorpromazine groups were 11 mg dl and 4 mg dl respectively.