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Highly protein-bound drugsFeldene is highly protein-bound and therefore might be expected to displace other protein-bound drugsThe physician should closely monitor patients for change when administering Feldene to patients on highly protein-bound drugs.

Life-threatening cutaneous reactionsStevens-Johnson syndromeSJSand toxic epidermal necrolysisTENhave been reported with the use of piroxicam.

Inform patients of the warning signs and symptoms of hepatotoxicitye.gnauseafatiguelethargydiarrheapruritusjaundiceright upper quadrant tendernessandflu-likesymptomsIf clinical signs and symptoms consistent with liver disease developor if systemic manifestations occure.geosinophiliarashetcdiscontinue FELDENE immediatelyand perform a clinical evaluation of the patient.

Advise patients to report symptoms of ulcerations and bleedingincluding epigastric paindyspepsiamelenaand hematemesis to their health care providerIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxisinform patients of the increased risk for and the signs and symptoms of GI bleedingsee WARNINGS AND PRECAUTIONS

A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsFELDENE is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen FELDENE is used in patients with preexisting asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.

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