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The principal and potentially serious toxic effects of IMURAN are hematologic and gastrointestinalThe risks of secondary infection and malignancy are also significantsee WARNINGSThe frequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient’s underlying disease or concomitant therapiesThe incidence of hematologic toxicities and neoplasia encountered in groups of renal homograft recipients is significantly higher than that in studies employing IMURAN for rheumatoid arthritisThe relative incidences in clinical studies are summarized below:

IMURAN is indicated as an adjunct for the prevention of rejection in renal homotransplantationIt is also indicated for the management of active rheumatoid arthritis to reduce signs and symptoms.

Maintenance dosage should range from 1 to 4 mg/kg bodyweight/day and must be adjusted according to clinical requirements and haematological tolerance.

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