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The risk of heart diseaseliver diseaseand high blood pressure increases with ageOlder adults may be more sensitive to the side effects of this drugespecially increased blood pressure and heart problems.

Significant elevation in blood pressureincluding hypertensive crisis with acute impairment of organ systemshas been reported on rare occasions in patients treated with 5-HT1 agonistsincluding patients without a history of hypertensionMonitor blood pressure in patients treated with ImitrexImitrex tablets are contraindicated in patients with uncontrolled hypertension.

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Frequency not reportedAcquired musculoskeletal deformityarthralgiaarthritisarticular rheumatitisdifficulty in walkingintervertebral disc disordermuscle atrophymuscle tightness and rigiditymusculoskeletal inflammationrigiditytetanytwitchingRef]

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