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Fluticasone propionate is a substrate of CYP3A4The use of strong CYP3A4 inhibitorse.gritonaviratazanavirclarithromycinindinaviritraconazolenefazodonenelfinavirsaquinavirketoconazoletelithromycinconivaptanlopinavirnefazodonevoriconazolewith FLONASE Nasal Spray is not recommended because increased systemic corticosteroid adverse effects may occur.
Inform patients that treatment with FLONASE Nasal Spray may lead to adverse reactionswhich include epistaxis and nasal ulcerationCandida infection may also occur with treatment with FLONASE Nasal SprayIn additionFLONASE Nasal Spray has been associated with nasal septal perforation and impaired wound healingPatients who have experienced recent nasal ulcersnasal surgeryor nasal trauma should not use FLONASE Nasal Spray until healing has occurredsee WARNINGS AND PRECAUTIONS
Hypoadrenalism may occur in infants born of mothers receiving corticosteroids during pregnancySuch infants should be carefully monitored.
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