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Your doctor should do blood tests to check your liver before starting treatment and if you have symptoms of liver problems while taking CRESTOR Call your doctor right away if youHave unexplained muscle pain or weaknessespecially with fever Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR Feel unusually tired Have loss of appetiteupper belly paindark urineor yellowing of skin or eyesThese could be signs of rare but serious side effects Elevated blood sugar levels have been reported with statinsincluding CRESTOR Side effectsThe most common side effects may include headachemuscle achesabdominal painweaknessand nauseaMemory loss and confusion have also been reported with statinsincluding CRESTOR Tell your doctor and pharmacist about other medicines you are taking.

Other adverse reactions reported in clinical studies were abdominal paindizzinesshypersensitivityincluding rashpruritusurticariaand angioedemaand pancreatitisThe following laboratory abnormalities have also been reporteddipstick-positive proteinuria and microscopic hematuriasee WARNINGS AND PRECAUTIONSelevated creatine phosphokinasetransaminasesglucoseglutamyl transpeptidasealkaline phosphataseand bilirubinand thyroid function abnormalities.

Rosuvastatin significantly reduced LDL-Cprimary end pointtotal cholesterol and ApoB levels at each dose compared to placeboResults are shown in Table 12 below.

Rosuvastatin was not mutagenic or clastogenic with or without metabolic activation in the Ames test with Salmonella typhimurium and Escherichia colithe mouse lymphoma assayand the chromosomal aberration assay in Chinese hamster lung cellsRosuvastatin was negative in the in vivo mouse micronucleus test.

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