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CyclophosphamideCombination therapy with cyclophosphamide and fluconazole results in an increase in serum bilirubin and serum creatinineThe combination may be used while taking increased consideration to the risk of increased serum bilirubin and serum creatinine.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofliver diseasekidney disease.

Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitorFluconazole is also a strong inhibitor of CYP2C19Diflucan treated patients who are concomitantly treated with medicinal products with a narrow therapeutic window metabolised through CYP2C9CYP2C19 and CYP3A4should be monitoredsee section 4.5

Many drugs can interact with fluconazoleand some drugs should not be used togetherThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guideTell your doctor about all your current medicines and any medicine you start or stop using.

The evidence for efficacy of fluconazole in the treatment of other forms of endemic mycoses such as paracoccidioidomycosislymphocutaneous sporotrichosis and histoplasmosis is limitedwhich prevents specific dosing recommendations.

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different patients need more or less diflucan fluconazole depending on their physiology, chronicity of the conditions, and how they respond to the medication.

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