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Assess blood pressure before initiating treatment with sustained release formulationand monitor periodically during treatmentrisk of hypertension is increased if sustained release formulation is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activityuse caution in patients with cardiovascular disease.

Bupropion is also sometimes used to treat episodes of depression in patients with bipolar disordermanic depressive disordera disease that causes episodes of depressionepisodes of maniaand other abnormal moodsand to treat attention deficit hyperactivity disorderADHDmore difficulty focusingcontrolling actionsand remaining still or quiet than other people who are the same ageTalk to your doctor about the possible risks of using this medication for your condition.

You should know that your mental health may change in unexpected ways when you take bupropion or other antidepressants even if you are an adult over age 24 or if you do not have a mental illness and you are taking bupropion to treat a different type of conditionYou may become suicidalespecially at the beginning of your treatment and any time that your dose is increased or decreasedYouyour familyor your caregiver should call your doctor right away if you experience any of the following symptomsnew or worsening depressionthinking about harming or killing yourselfor planning or trying to do soextreme worryagitationpanic attacksdifficulty falling asleep or staying asleepaggressive behaviorirritabilityacting without thinkingsevere restlessnessand frenzied abnormal excitementBe sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietydepressionpanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallyor have thoughts about suicide or hurting yourself.

Do not take this medicine to treat more than one condition at a timeIf you take bupropion for depressiondo not also take this medicine to quit smoking.

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